PGS vs PGD Fees in Czechia, Pronatal

4 Preimplantation Genetic Screening/ Diagnosis ‘Core’ Bundles: ‘Pre–PGS/PGD and post–PGS/PGD’, ‘Preimplantation Genetic Screening (PGS)/ Preimplantation Genetic Diagnosis (PGD) biopsy’ (unlimited no. of biopsied embryos), ‘PGS (Preimplantation Genetic Screening) of all 24 chromosomes’, ‘PGD — Preimplantation Genetic Testing for monogenic diseases (PGT–M)’. Plus ‘Predicting transmission risk for de novo mutation that may cause disease in children’ screening Bundle. And ‘Genetic Compatibility Test for the couple’ Bundle Pro. Explore which pack is right for you. Starting at 2,000.00 EUR per cycle.

1. ‘Where can I pre–order or book the IVF pack?’

Located in Prague, Bubeneč, Karlovy Vary, Kolin, and Teplice, Czechia, Pronatal IVF Center has been successfully providing multiple options for IVF Treatment for 20+ years. Pronatal IVF Center specializes in performing Gynecology & Mammalogy, Urology & Andrology, Pregnancy Planning & Care, Procedures & Manipulations, Laboratory Tests & Genetic Analysis, Infertility Screening & Treatment, Surgical Treatment, MESA & TESE, Ovulation Induction (OI) cycles, IUI (Intrauterine Insemination) cycles, IVF, ICSI & PICSI cycles, Oocyte & Sperm Donation, Egg & Sperm Cryopreservation and Storage, Embryo Vitrification & Storage, Legal Support & Assistance. Explore all ‘core’ in–Bundle and out–Bundle configurations designed for IVF programs.

2. The available packs and their costs: ‘PGD (Preimplantation Genetic Diagnosis)’ and PGS (Preimplantation Genetic Screening)’.

Preimplantation Genetic Screening/ Diagnosis ‘Core’ Bundles and their fees.

2.1. Pre–PGS/PGD and post–PGS/PGD configurations all beautifully packed in one Bundle:

Pack no. 1: ‘Pre–PGS/PGD and post–PGS/PGD’: ICSI–Embryo Generation (fertilization of up to 10 oocytes using the partner’s or donor’s sperm), post–fertilization prolonged Embryo Cultivation cycle (until the blastocyst stage) for the whole embryonic cohort generated through ICSI using the Time–Lapse incubator, Assisted Hatching, and EmbryoGlue for the Embryo Transfer

Bundle’s cost starts at 1,330.00 EUR.

‘What is in the Bundle?’

1 ICSI–Embryo Generation cycle using the donor’s oocytes and the partner’s sperm (up to 10 oocytes can be fertilized).
1 post–fertilization prolonged Embryo Cultivation cycle (until the blastocyst stage) for the whole embryonic cohort generated through ICSI using the Time–Lapse incubator with integrated embryo monitoring system with continuous time–lapse imaging to capture critical developmental stages without causing potential stress to the embryos.
1 Assisted Hatching cycle for the embryos with low hatching potency.
EmbryoGlue for boosting the embryo implantation potency (Hyaluronic Acid (HA)–enriched Embryo Transfer medium).

2.2. PGS (Preimplantation Genetic Screening)/PGD (Preimplantation Genetic Diagnosis) biopsy:

’Preimplantation Genetic Screening (PGS)/ Preimplantation Genetic Diagnosis (PGD) biopsy’ (unlimited no. of biopsied embryos) — 430.00 EUR.

2.3. PGS (Preimplantation Genetic Screening) Bundles:

Pack no. 1: ‘PGS (Preimplantation Genetic Screening) of all 24 chromosomes’ designed and powered up for 4 embryos.

Pack no. 1: ‘PGS (Preimplantation Genetic Screening) of all 24 chromosomes in embryos (powered up for screening up to 4 embryos)’: PGS of all 24 chromosomes for chromosomal aneuploidies in up to 4 embryos generated through the ICSI–‘session’ (24–chromosome diagnosis consistency with the highly validated a–CGH (array/microarray comparative genomic hybridization) / NGS (Next–Generation Sequencing) / or both a–CGH and NGS techniques powered up for the same embryos, identification of euploid blastocysts for transfer using NGS screening/ a–CGH screening, creation of the personalized profile for each embryo from the screened embryonic cohort, and selection of the euploid blastocysts suitable for Embryo Transfer

Bundle’s cost starts at 2,000.00 EUR per cycle.

‘What is in the Bundle?’

PGS of all 24 chromosomes for chromosomal aneuploidies designed and powered up for screening of up to 4 embryos generated through the ICSI–‘session’ (24–chromosome diagnosis consistency with the highly validated a–CGH (array/microarray comparative genomic hybridization) or NGS (Next–Generation Sequencing), or both a–CGH and NGS techniques from the same embryos).
identification of euploid embryos (embryos that contain a normal number of chromosomes) and aneuploid embryos (embryos that contain an abnormal number of chromosomes) using NGS Screening/ a–CGH screening.
dividing the embryonic cohort into 2 cohorts: euploid and aneuploid embryos.
creation of the personalized profile for each embryo from the screened embryonic cohort.
selection of the euploid blastocysts suitable for Embryo Transfer.

Pack no. 2: ‘PGS (Preimplantation Genetic Screening) of all 24 chromosomes designed and powered up for 5–8 embryos.

Pack no. 2: ‘PGS (Preimplantation Genetic Screening) of all 24 chromosomes in embryos (powered up for screening 5–8 embryos)’: PGS of all 24 chromosomes for chromosomal aneuploidies in 5–8 embryos generated through the ICSI–‘session’ (24–chromosome diagnosis consistency with the highly validated a–CGH (array/microarray comparative genomic hybridization) / NGS (Next–Generation Sequencing) / or both a–CGH and NGS techniques powered up for the same embryos, identification of euploid blastocysts for transfer using NGS screening/ a–CGH screening, creation of the personalized profile for each embryo from the screened embryonic cohort, and selection of the euploid blastocysts suitable for Embryo Transfer

Bundle’s cost starts at 3,000.00 EUR per cycle.

‘What is in the Bundle?’

PGS of all 24 chromosomes for chromosomal aneuploidies designed and powered up for screening of 5–8 embryos generated through the ICSI–‘session’ (24–chromosome diagnosis consistency with the highly validated a–CGH (array/microarray Comparative Genomic Hybridization) or NGS (Next–Generation Sequencing), or both a–CGH and NGS methods from the same embryos).
identification of euploid embryos (embryos that contain a normal number of chromosomes) and aneuploid embryos (embryos that contain an abnormal number of chromosomes) using NGS screening/ a–CGH screening.
dividing the embryonic cohort into 2 cohorts: euploid and aneuploid embryos.
creation of the personalized profile for each embryo from the screened embryonic cohort.
selection of the euploid blastocysts suitable for Embryo Transfer.

Extra embryo screened:

PGS (Preimplantation Genetic Screening) of all 24 chromosomes for chromosomal aneuploidies designed and powered up for screening each additional embryo starting from the 6^th preimplantation embryo by a–CGH or NGS — 300.00 EUR per 1 embryo.

2.4. PGD — Preimplantation Genetic Diagnosis for monogenic diseases (PGT–M refers to testing for DNA pathogenic variant(s) causing monogenic disorders (combinations of monogenic disorders) screening Bundles.

Pack no. 1: ‘PGD (Preimplantation Genetic Diagnosis)’ Screening Bundle powered up before the first PGD cycle only.

Pack no. 1: ‘PGD (Preimplantation Genetic Diagnosis)’ Screening Bundle powered up before the first PGD cycle only: prep. for PGD (PGT–M) and family screening cost starts at 500.00 EUR per cycle.

Pack no. 2: ‘Predicting transmission risk for de novo mutation that may cause disease in children’.

Pack no. 2: ‘Predicting transmission risk for de novo mutation that may cause disease in children’: prep. for screening, the partner’s sperm screening for de novo mutations, identification of the germ line with mutations and unique mutational signatures, creation of the personalized profile with the post–screening results

Bundle’s cost starts at 1,000.00 EUR per cycle.

Errors in DNA copying during cell division and development can cause new mutations (de novo mutations) — at any time from the moment of conception. Mutations that occur in the germ line — the cells that develop into spermatozoa or oocytes — can be passed on to the next generation, causing disease in children.

Pack no. 3: ‘PGD — Preimplantation Genetic Testing for monogenic diseases (PGT–M)’.

Pack no. 3: ‘Preimplantation Genetic Testing for monogenic diseases (PGT–M) powered up for screening the embryonic cohort generated through the single ICSI session’: Preimplantation Genetic Testing for monogenic diseases (PGT–M) powered up for the embryonic cohort generated through the single ICSI session, identification of embryos with monogenic diseases’ content and those that are free from monogenic diseases, creation of the personalized profile for each embryo from the screened embryonic cohort, and selection of the normal blastocysts suitable for Embryo Transfer

Bundle’s cost starts at 2,500.00 EUR per cycle.

‘What is in the Bundle?’

Preimplantation Genetic Testing for monogenic diseases (PGT–M) powered up for the embryonic cohort generated through the single ICSI session.
identification of embryos with monogenic diseases’ content and those that are free from monogenic diseases.
creation of the personalized profile for each embryo from the screened embryonic cohort.
selection of the normal blastocysts suitable for Embryo Transfer

Preimplantation Genetic Testing for monogenic diseases (PGT–M refers to testing for DNA pathogenic variant(s) causing monogenic disorders (combinations of monogenic disorders), X–linked, autosomal dominantly or recessively inherited.

2.5. Genetic Testing for couples planning a pregnancy.

Pack no. 1: ‘Genetic Compatibility Test for the couple’: prep. for Genetic Compatibility Test, Genetic Compatibility Test, post–screening personalized profile generation with the obtained through screening results

Bundle’s cost starts at 310.00 EUR per screening.

Something to say in conclusion?

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