SUMMARY: In FIV Marbella we offer standard IVF cycles, flexible IVF cycles and guaranteed IVF cycles (multi–cycled IVF bundles), IVF cycles with prolonged embryo culturing (with blastocyst transfer), IVF cycles with multi–attempts, IVF cycles with egg donation, IVF cycles with sperm donation, IVF cycles with triple sperm selection technique, IVF cycles with embryo adoption, IVF cycles with cryo–transfer, IVF cycles with PGD/PGS screening techniques (and every our IVF cycle has one Top Option: multi–synchronization of additional techniques and options that are “tuned up” exclusively for every case).
PRICE: IVF (in vitro fertilization) package: Price on Request.
BASIC PACKAGE FEE COVERS:
THE TIME FRAME: 20 days — 30 days.
IVF cycle’s approximate time frame (without pre–treatment screening tests time frame) is 20 days. IVF cycle’s approximate full time frame (with pre–treatment screening tests) and prolonged embryo culturing is 25–30 days.
More details about IVF with oocyte donation (IVF with egg donation) package and IVF cycle in FIV Marbella.
IVF cycles with oocyte donation (IVF with donated oocytes) are an exclusive option for the cases when it is impossible to use own oocytes for fertilization. The issues when the patient cannot produce healthy oocytes is called “ovarian failure.” The lack of oocytes in the ovaries because of the premature menopause is also the strong indicator for designing IVF cycle with oocyte donation option.
IVF cycles with oocyte donation are the dual–staged ones. The oocyte donor is selected according to the set criteria: with the same physical characteristics, with the similar appearance (as it is vital for the couple to have the tiny one looking like his or her mother (having the resemblance with the mother), with the blood group (as the patient), with the similar genetic content (to exclude the genetic abnormalities, chromosomal abnormalities, and abnormalities that affect the genomes). La cual ha pasado por exhaustivas pruebas y análisis para descartar la presencia de enfermedades como el VIH o la Hepatitis, entre otros.
The oocyte donor is screened before the IVF cycle. After the pre–treatment screening results are obtained, the oocyte donor undergoes ovarian stimulation and oocyte retrieval (oocyte pick–up) procedure.
The patient undergoes pre–treatment screening tests and the endometrium preparation cycle. The endometrium preparation protocol is drafted, discussed and implemented prior the oocyte’s fertilization “event.” The patient is prescribed the oral estrogen or transdermal patches to prepare her uterus for the actual embryo transfer synchronously with the oocyte donor’s ovarian stimulation cycle.
The partner’s or donor’s sperm is collected and prepared for further fertilization the same day as the oocyte donor has her oocyte retrieval (oocyte pick–up) procedure.
Collected oocytes are comprehensively investigated, fertilized with the partner’s sperm or with the donor’s sperm. After fertilization, the newly generated embryos are cultured into the incubator (2–5 days), and their development is continuously monitored by the embryologist.
The patient’s endometrium preparation is monitored via ultrasound scans and blood tests. This dual–control authentication system turns it possible to visualize what is “going on inside,” and to show the time frame for the actual embryo transfer according to the stage of the endometrium receptivity, thus boosting the embryo implantation chances.
The time frame for the actual embryo transfer is chosen and scheduled. Prior to embryo transfer, the embryos are investigated, and the top–quality embryos (usually one or two) are chosen for the embryo transfer. The remaining viable embryonic cohort is vitrified on the same day for future frozen embryo transfer cycles.
Ultimately, the embryo transfer is performed and the pregnancy test is scheduled in two weeks after the embryo transfer. If the pregnancy test is positive, the fertility expert will schedule the early ultrasound scan that would visualize the embryonic heart activity as early as week 6 or week 8.
What is IVF (in vitro fertilization) technique?
IVF or in vitro fertilization is the POWERFUL technique that is used for fertilization of every mature oocyte with sperm with or without ICSI or IMSI technique with further embryo culturing “event” and embryo transfer “event.”
The “content” and “configuration” in every IVF cycle is authentic as there are different techniques and options that are synchronized for every case, starting from fertilization technique, embryo culturing and embryo monitoring, helping the embryo to hatch outside, preparing maternal endometrium for embryo launching event and completing with PGS (preimplantation genetic screening), PGD (preimplantation genetic diagnosis) for screening the embryonic content and identifying in chromosomal profiles’ the abnormalities and embryo vitrification for the next frozen embryo transfer (FET) cycles.
Dual–staged (oocyte pick–up and fresh embryo transfer) or more, with minimal, moderate or intensive ovarian stimulation protocol, with ICSI (IMSI) fertilization technique or without, with prolonged time frame for embryo transfer event or more, with laser–assisted hatching or without, with PGS NGS screening or without, with PGD or without, with frozen or fresh embryo transfer, — every IVF cycle is different in its core.
Drafted with FLEXIBLE strategies and variety of techniques and options, “previewed” and discussed, synchronized by connecting the most POWERFUL strategies and EFFECTIVE techniques that can be implemented for this case, every IVF cycle is taken to the next level and completed in the most brilliant way.
PRICE on REQUEST.
Why there is no approximate IVF package cost?
Every IVF bundle designed in FIV Marbella is authentic and involves the synchronization of techniques and options that are ideal for this case. There are no identical strategies that can be implemented in every IVF cycle. There are no ideal IVF bundles that are effective for every case as every case is authentic in its core. Every IVF cycle’s total cost may vary from its approximate as the time–frame for pre–treatment screening is different. Starting from controlled ovarian stimulation medications (for mild, moderate or intensive) and completing with the embryo transfer event timeline.
One can have normal hormonal levels and the ovarian stimulation will be “performed” without “tuning up” the stimulation protocol. The other one can have issues with hormonal levels, therefore, ovarian stimulation protocol will be “tuned up” several times and the medications will be changed, thus, the time–frame for ovarian stimulation will be prolonged. In another case, the PGD (preimplantation genetic diagnosis) screening will be synchronized with IVF basic package, thus, embryo transfer will be performed not in six days and embryo vitrification plus embryo thawing will be done prior to embryo transfer event. These “small details” affect the total IVF package cost.
The time frame:
IVF cycle’s approximate time frame (without pre–treatment screening tests time frame) is 20 days. IVF cycle’s approximate full time frame (with pre–treatment screening tests) and prolonged embryo culturing is 25–30 days.
Making the IVF “Roadmap’s Milestones” “visible”.
IVF cycle in FIV Marbella explained step–by–step:
STEP 1 | INITIAL CONSULTATION with FIV Marbella Fertility Expert (or with FIV Marbella Fertility Experts, in case if necessary).
During the initial consultation with FIV Marbella expert, the oocyte donor will be selected according to the set criteria: with the same physical characteristics, with the similar appearance (as it is vital for the couple to have the tiny one looking like his or her mother (having the resemblance with the mother), with the blood group (as the patient), with the similar genetic content (to exclude the genetic abnormalities, chromosomal abnormalities, and abnormalities that affect the genomes). La cual ha pasado por exhaustivas pruebas y análisis para descartar la presencia de enfermedades como el VIH o la Hepatitis, entre otros.
After that, your FIV Marbella fertility expert will draft your dual–staged IVF cycle: drafting the one stage of IVF cycle for the oocyte donor, and the second stage of the IVF cycle for you. For the oocyte donor, FIV Marbella fertility expert will draft ovarian stimulation protocol, the medications’ list for controlled ovarian stimulation cycle, schedule the ultrasound “management” of ovarian stimulation, plus schedule the pre–treatment screening tests.
For you, FIV Marbella fertility expert will draft endometrium preparation protocol, the medications’ list for controlled endometrium preparation, schedule the ultrasound “management” of endometrium preparation, plus schedule the pre–treatment screening tests.
STEP 2 is started for you and for the oocyte donor synchronically, therefore, it is ‘labeled’ step 2 for you both.
STEP 2 | Oocyte donor’s preparation for IVF cycle.
Pre–treatment screening tests and blood tests are performed for making the “tuning up” of the drafted IVF protocol according to the obtained results. The medications (fertility drugs) for ovarian stimulation and injectable hormones are prescribed for the oocyte donor.
SPEP 2 | Your preparation for IVF cycle.
You will also undergo pre–treatment screening tests and have blood tests. After that, FIV Marbella fertility expert will tune up the endometrium preparation protocol according to the obtained results. The medications (oral estrogen or transdermal patches) for controlled endometrium preparation will be prescribed, and you will start the cycle right away.
STEP 3 | CONTROLLED EGG DONOR’S OVARIAN STIMULATION and ITS MONITORING.
In vitro fertilization technique is characterized by the union of an oocyte and a spermatozoon (fertilization) is performed in the laboratory. This technique requires the implementation of a controlled ovarian stimulation protocol, thus, using gonadotropins subcutaneously and the management of the controlled ovarian stimulation cycle via ultrasound monitoring. Analytical control of the hormonal levels, analytical control of the hormonal balance, and analytical control of estradiol hormone indicates the oocytes’ maturity. Alternatively, ultrasound scans “visualize” the follicle maturation and the timeline for triggering the ovulation (for scheduling the TRIGGER SHOT — an injection done to prevent spontaneous ovulation (losing the mature oocytes).
STEP 4 | TRIGGER SHOT (for the oocyte donor).
The trigger shot is injected to prevent self–ovulation and making oocytes’ collection accessible. After the trigger shot is done, there will be a short timeline for the egg donor to get ready for the ultrasound–guided oocyte retrieval procedure.
STEP 5 | OOCYTE RETRIEVAL (the egg donor undergoes oocyte pick–up procedure).
The egg retrieval procedure is an invasive one, therefore, it is performed in an operating theatre. Prior to oocyte pick–up, the oocyte donor will be sedated. The oocyte pick–up surgery usually lasts 10–15 minutes. This procedure is performed under ultrasound guidance: a fine needle “punctures” the follicles and the oocytes with liquid are collected from the follicles and transferred to the laboratory for further investigation and fertilization. Ideally, 8–10 mature oocytes will be retrieved. After that, the oocyte donor is discharged, and the recovery timeline takes 24–48 hours.
STEP 6 | SPERM COLLECTION and SPERM PREPARATION
The partner’s/husband’s/donor’s sperm is collected and prepared for fertilization in the same time frame when the oocyte retrieval is performed.
STEP 7 | FERTILIZATION
After the oocyte retrieval, all collected oocytes are transferred to the laboratory for further “validation”. Only mature oocytes will be fertilized with the partner’s/husband’s/donor’s sperm. The fertilization technique is chosen and performed (conventional fertilization, ICSI, or IMSI).
If conventional fertilization is chosen, the oocytes and sperm cells are placed in the Petri–dish for self–fertilization event. The timeframe for conventional fertilization is 24 hours.
If ICSI or IMSI fertilization technique is chosen, then every oocyte is fertilized through microinjection by the ICSI micro–pipette where one single top–quality spermatozoon is placed and transferred directly into the oocyte’s cytoplasm. ICSI or IMSI technique involves using the IVF workstation or inverted micromanipulation workstation with micromanipulation platform.
Currently, some IVF centers have a new microscope that allows this technique to be performed with much higher magnification, being much more precise in the selection and injection of sperm, it is called IMSI.
STEP 8 | EMBRYO CULTURING
Once the oocytes are fertilized with sperm, it is now called “an embryo” which is left to grow in special culture media, usually for three days following a rigorous process of observation of their morphology and cell number. The embryonic cohort for embryo transfer, even being large has its own criteria. Some embryos are mosaic and should be excluded from the embryonic cohort that is ideal for further embryo transfer event. Some embryos may stop their development and cannot be transferred because they are not viable.
In some cases, the embryo is left to grow up to six days (blastocyst stage) in order to select more rigorously their morphology and decide which are most likely to implant in the uterus of the patient after Embryo Transfer and which are susceptible for freezing (Embryo Vitrification).
STEP 9 | EMBRYO TRANSFER
Embryo transfer is a simple, non–invasive, painless, short–time procedure that does not need anesthesia or sedative medications. It is scheduled and performed on day 3 or day 6 (embryo culturing). One or two embryos are transferred into the maternal uterus through a special flexible tube (catheter). Embryo transfer is performed on an outpatient basis and after embryo transfer is completed, the patient is recommended to rest for 24—48 hours.
STEP 10 | EMBRYO VITRIFICATION
On the day of embryo transfer “event”, remaining viable embryos are frozen using a vitrification technique, for future transfer in a subsequent cycle without starting an ovarian stimulation protocol and oocyte retrieval. Embryo freezing (embryo cohort freezing) for further frozen embryo transfer cycles is an essential component of a successful IVF, with vitrification technique providing top embryo survival ratings and excellent pregnancy outcomes. Every couple and every patient can choose embryo vitrification and embryo storage for future FET cycles.
STEP 11 | PREGNANCY TEST
Two weeks after the embryo transfer “event”, the patient will return to FIV Marbella for a pregnancy test. The blood test will be performed to measure hCG hormone levels and if they are increased, the pregnancy is achieved. hCG hormone is a specific hormone that is produced by the placenta after the embryo implantation event.
The urinary test will be performed two weeks later. If the patient is pregnant, the early ultrasound scan will be pre–scheduled in two or three more weeks (early ultrasound detects embryonic heart activity starting from week 6 or week 7 in pregnancy).
STEP 12 | EARLY ULTRASOUND SCAN
Early ultrasound scan is performed to detect the heart activity of the embryo and to confirm the pregnancy. If the ultrasound technician can see the sparkling dot on the screen that is the embryonic heart. If the embryonic heart has a normal heartbeat rate, that seems that embryo is viable and the embryonic heart is developing.
FIV Marbella IVF journey
Every IVF journey is unique. Every IVF cycle is authentic. Every embryo generated by IVF is a real Miracle. In FIV Marbella you will never go through IVF journey alone. You will be always “in touch” with the excessively experienced team of leading experts, navigating you throughout every IVF stage.